Co-Q10 as an anti-depressant

Bipolar disorder is a mental illness causing dramatic switches in a person’s mood, energy and clarity of thought. This presents as phases of mania and depression, the highs and lows of which are far more dramatic than what the typical person experiences. 

Average age-of-onset of bipolar is in the mid 20‘s but the condition can occur in teenagers too, less commonly in childhood Unfortunately, if it is left untreated, bipolar disorder often worsens. 

Among the biochemical factors underlying these symptoms are mitochondrial dysfunction, abnormal cellular energy production and overproduction of oxidative stress, causing inflammation in the brain. 

Lower serum levels of Co-enzyme Q10 are observed in patients with depression. A published study in the Journal of Clinical Psychopharmacology aimed to evaluate the effect of CoQ10 as an adjuvant treatment during the depressive phase of bipolar disorder. 89 bipolar patients experiencing a current depressive episode were received either adjuvant CoQ10

(200mg/day) or placebo for 8 weeks. Whilst both groups experienced reductions in depression scores according to the Montgomery-Asberg Depression Ratings Scale (MADRS) from baseline to week 4, the CoQ10 group experienced a significantly greater reduction from week 4 to week 8 of the study. After 8 weeks, more patients in the CoQ10 group responded to treatment. 

Several conventional treatments for bipolar disorder are known to have anti-inflammatory and antioxidant properties such as atypical antipsychotics, lithium, lamotrigine and sodium valproate, and may be one pathway by which these drugs improve symptoms. Evidence is also emerging for other natural agents with well-known antioxidant and anti-inflammatory activity suchas N-acetyl-cysteine (NAC), vitamin C and EPA from fish oil, in the management of both unipolar and bipolar depression. These treatments will also go a long way in the prevention of further health issues and prevention of advanced ageing for these individuals.

If you have any concerns about your mental health, I encourage you to contact me so we can assess your specific needs.

in health, Julie 

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